Prenatal Exposure to Progesterone Affects Sexual Orientation in Humans

If You are Gay, the Chances are this is Why

Prenatal sex hormone levels affect physical and behavioral sexual differentiation in animals and humans.

Although prenatal hormones are theorized to influence sexual orientation in humans, evidence is sparse.

 Compared to the unexposed, fewer exposed males and females identified as heterosexual and more of them reported histories of same-sex sexual behavior, attraction to the same or both sexes, and scored higher on attraction to males

Researchers observed consistent findings across samples of men and women prenatally exposed to exogenous progesterone for a set of variables directly reflective of sexual orientation.
Physicians often prescribe progesterone and its bio-versions to support the fertilization process, to prevent miscarriages or premature births, or to increase babies’ birth weights.

Progesterone plays a role in neural development and the production of other sex hormones as well as steroid hormones that help to regulate stress responses, inflammation, and metabolism in the body. Men and women all naturally produce the sex hormone

Measures of heterosexual behavior and scores on attraction to females did not differ significantly by exposure. Among progesterone-exposed cases, non-heterosexual identity was shown to be associated with higher total dosages and longer duration of prenatal exposure to progesterone.

Dr. June Reinisch, director emerita of the Kinsey Institute in the U.S., led the study. She found that bisexuality is quite common among men and women whose mothers received additional doses of the sex hormone progesterone while pregnant.

It was found that men and women whose mothers were treated with progesterone were significantly less likely to describe themselves as heterosexual. One in every five (20.6 percent) of the progesterone- exposed participants labeled themselves as other than heterosexual.

Compared to the untreated group, the chances were greater that by their mid-20s they had already engaged in some form of same-sex sexual behavior (in up to 24.2 percent of cases), and that they were attracted to the same (29.4 percent) or to both sexes (17.6 percent). Both exposed males and females also had higher scores related to attraction to men.

Since Facebook where many read this seems to be populated with many who are dead from the neck up and refuse to read the actual medical research (too many big words?)

We point out that the link to the research is right here.

And really to those who have deep and serious questions about anything that challenges there preconceptions, here are institutions at which the five lead researchers on the study are working:

  1. The Kinsey Institute for Research in Sex, Gender and ReproductionIndiana UniversityBloomingtonUSA
  2. 2.The Museum of SexNew YorkUSA
  3. 3.Institute of Preventive MedicineCopenhagen University HospitalCopenhagenDenmark
  4. 4.Department of Public HealthUniversity of CopenhagenCopenhagenDenmark
  5. 5.Department of Gender StudiesIndiana UniversityBloomingtonUSA


This bioassay makes it clear that exposure to exogenous progesterone during a sensitive period of human CNS differentiation may permanently affect neural function and ultimately influence later behavior.
The author  conclude that, regardless of sex, exposure appeared to be associated with higher rates of bisexuality.
Prenatal progesterone may be an underappreciated epigenetic factor in human sexual and psychosexual development and, in light of the current prevalence of progesterone treatment during pregnancy for a variety of pregnancy complications, warrants further investigation.
These data on the effects of prenatal exposure to exogenous progesterone also suggest a potential role for natural early perturbations in progesterone levels in the development of sexual orientation.
NOTE: This is precisely what we discussed in our interview on Wrong Think Radio
Today’s Epidemics: How they Happen in the Womb
Trans, Obesity, Depression: All Just Un-Balanced Brain-Body Hormone Loops
This research tells us  that the gays and lesbians (such as Milo Yiannopoulos..a notorious Trans basher and various feminists, just for examples) are in exactly the same boat as Transgender people  – brain damage in the womb.
 This applies to many, many millions more than just the Trans.  And it applies to all the mothers and mothers-to-be who are being poisoned during pregnancy with Progesterone or progestagens that can do even more harm.
Mostgay persons or trans persons are not “conceived that way” i.e. in their genes or with mutations, but “born that way” after their nine months in the womb because various hormonal disruptions in their mothers womb alter their sexual preferences or sexual identities or other aspects of function impacted by alterations in brain development  This is very much like the way the Trans person is impacted by hormonal disruption in the womb.
It Trans folks are  “crazy”  or suffering a mental disorder then so are gay people. To say that either is “born that way “ is not clearly not true in both cases.
The only difference in etiology is likely one of specific time and place in the brain that some hormonal disruption occurs, either the time during the 9 month period and the locations with the vast genome and its methylated ‘wrappings in the brain”
Legally this research  should open the door to Trans and Gay on the same basis, albeit with different choices of life enhancing strategies that they might follow.  Or if Trans person are claimed to be “insane” in some way, the same would go for Gays.  Once we accept that both these types of persons as well as others manifesting other conditions arising during the same period in the womb at the same and or other locations in the genome are equivalently physiologically impact by these events during gestation, then we, as a society, owe them the opportunity to cope as best they think fit with the steps they take towards optimal adaptation and life success.
As to the immediate issue of progesterone poisoning of pregnenat women by the medical profession  it is vital, because hundreds of thousands of women are likely to be treated with varying amounts and types of progesterone right now…as we speak…and that means further augmentation of the levels of both trans and gay kids
Lastly, the research does not discuss the aspect of the multiplacation of these conditions via transmission to children and grandchildren and greatgrandchildren of the mothers exposed to progesterone and other disruptors  this in the study but it is likely a condition and imbalance in genome status which is transmissible over generations so we should not be surprised to see the logarithmic increase in all these conditions.
This is only the tip of the iceberg, since such conditions as autism and ADHD are directly related to the same sorts of events…and often the very same loci of action on the genome.
It is also possible that medical treatment with progesterone is a marker of maternal progesterone deficiency and that variation in endogenous maternal progesterone levels may be an important factor in naturally occurring differences in sexual orientation.
The detection of a relationship between prenatal exposure to exogenous progesterone and sexual orientation in early adulthood, despite many intervening factors, supports the hypothesis that the prenatal hormone environment is influential.
 In considering the epigenetic mechanism(s) by which prenatal exposure to exogenous progesterone may influence sexual orientation, it is relevant that progesterone appears to have both antiandrogenic and antiestrogenic potential during early critical or sensitive periods of development
This hormonal medication was, and continues to be, administered by physicians to treat symptoms of staining, bleeding, to prevent prematurity in twins  and to prevent preterm birth  and for imminent spontaneous abortion  This demonstrates its capacity to have some meaningful physiological impact.
 It is currently used for pain, uterine contractions, and inadequate luteal phase, and its effectiveness has been demonstrated on both ultrasound assessment of uterine contraction and a pain scale  .
Exogenous progesterone has been demonstrated to have physiological effects during gestation despite the presence of high endogenous levels
 Exogenous progesterone administrated in association with in vitro fertilization has been suggested as a factor in increased rates of hypospadias in male newborns
Additionally, emerging research with rodents suggests progesterone and progesterone receptors may play an important role in the development of dimorphic sexual, cognitive, social, and affective behavior differentiation
How might the addition of exogenous progesterone into an already rich mixture of gestational steroids, including endogenous progesterone, affect the nervous system and subsequent behavioral development of the offspring?
First, in keeping with the most current clinical research,
Second, progesterone was administered exogenously at pharmacological levels during periods of gestation known to be sensitive to the influence of steroid hormones on sexual development
Third, exogenously introduced hormones may differ from (and thus have different potency than) their endogenous counterparts in how they are metabolized, their receptor affinity and sensitivity, and their systemic versus localized action.
Thus, it is possible that, compared to endogenous levels, even relatively limited physiological doses may have significant effects on various systems when administered exogenously.
 For more of Castalia’s Medical and Science Posts


    1. Hmmm Aurora ..I don’t know your source…but the article itself says, “we compared data on sexual orientation and attraction from young adults who were exposed in utero to progesterone (bioidentical progesterone = C21H30O2; MW: 314.46) via maternal medical treatment to data from unexposed matched controls. ”


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